Sensitive studies with a significant dose-response curve for inhaled corticosteroids to investigate equivalent relative potency are feasible
نویسندگان
چکیده
منابع مشابه
Significant variability in response to inhaled corticosteroids for persistent asthma.
BACKGROUND A clinical model is needed to compare inhaled corticosteroids (ICSs) with respect to efficacy. OBJECTIVE The purpose of this investigation was to compare the relative beneficial and systemic effects in a dose-response relationship for 2 ICSs. METHODS A 24-week, parallel, open-label, multicenter trial examined the benefit-risk ratio of 2 ICSs in persistent asthma. Benefit was asse...
متن کاملDose-response relationship for risk of non-vertebral fracture with inhaled corticosteroids.
OBJECTIVE To determine the strength of association between the dose of inhaled corticosteroids (ICS) and risk of non-vertebral fracture in adults. METHODS A systematic review and meta-analysis of case-control studies of non-vertebral fractures in adults, in which at least two doses of ICS were reported as the dose of beclomethasone dipropionate (BDP) or equivalent. RESULTS Five case-control...
متن کاملDose response of inhaled corticosteroids in children with persistent asthma: a systematic review.
OBJECTIVE To assess the dose-response relationship (benefits and harms) of inhaled corticosteroids (ICSs) in children with persistent asthma. METHODS We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) that compared ≥2 doses of ICSs in children aged 3 to 18 years with persistent asthma. Medline was searched for articles published between 1950 and August 2...
متن کاملAbsorption of high-dose inhaled corticosteroids.
The appropriate and safe use of inhaled corticosteroids (ICS) is an important issue in managing asthma, and we read with interest the article by Wales et al (June 1999).1 This is now the seventh report showing increased adrenal suppression with very high doses of fluticasone propionate (FP) compared to budesonide (BUD) in volunteers.2–7 However, normal subjects do not generally receive these do...
متن کاملPredictive value of the response to inhaled adenosine 5'-monophosphate for reducing the dose of inhaled corticosteroids in asthma.
BACKGROUND Guidelines recommend stepping down inhaled corticosteroids (ICS) in patients with well-controlled asthma. However, no information is available on the index that should be used to predict the outcome of reducing the ICS dose. OBJECTIVE The aim of this study was to investigate the degree of airway responsiveness to adenosine 5' monophosphate (AMP) as an index for deciding whether to ...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2011
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.2011.04017.x